Journal of
Systemics, Cybernetics and Informatics
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ISSN: 1690-4524 (Online)


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Editorial Advisory Board's Chair
William Lesso

Editor-in-Chief
Nagib C. Callaos


Sponsored by
The International Institute of
Informatics and Systemics

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Web X-Ray: Developing and Adopting Web Best Practices in Enterprises
Reinaldo Ferreira
(pages: 1-6)

The Use of MARIE CPU Simulator in Computer Architecture Course: A Case Study of Student's Perception of Learning and Performance
Jorge Fernando Maxnuck Soares, Luís Tadeu M. Raunheitte, Takato Kurihara
(pages: 7-13)

A Paradigm for Systems Thinking as a Real-Time Approach for Human Adaptation in the 21st Century
Melissa J. Mills
(pages: 14-21)

Exploring the Synergies between Teaching and Consulting: The Baldrige National Quality Award Experience
Ramachandran Natarajan
(pages: 22-25)

Now What? Think Fast: Using Healthcare Clinics as Universal Language to Maximize Learning for International Students in a Graduate Classroom
Sanda Katila
(pages: 26-37)

Quality Management in Education: A Comparative Case Study in Swedish Municipalities
Per-Olof Hansson, Elin Wihlborg
(pages: 38-42)

Introducing Problem-Solving Method in the Business School of a Brazilian University
Lilian A. P. Miguel, Adilson Caldeira
(pages: 43-48)

Academic Formation and Formative Research Integration Management for the Culmination of Studies Process in Higher Education
Lorna Cruz Rizo, Eneida Catalina Matos Hernández
(pages: 49-55)

Understanding the Process and Success Factors to Increase Synergies between Research and Teaching
Deborah Ballou, Brian Huguenard, Brian Nagy, Curtis Armstrong, Tor Guimaraes
(pages: 56-59)

Getting Smart: Need to Focus on Creating an Enabling Environment Structured Around the Objective of Realizing the True Potential of Our Next Generations
Hassan Sattar, Sadaf Nazir
(pages: 60-65)

How to Efficiently Conduct an IT Audit – In the Perspective of Research, Consulting and Teaching
Gabriel Felley, Rolf Dornberger
(pages: 66-70)

Breaking the Boundaries: Academic Applications of Multidisciplinary Research in Computer Science and Dentistry
Patricia Witt, José Ignacio Peláez, Gustavo Vaccaro
(pages: 71-75)


 

Abstracts

 


ABSTRACT


Design of Slit between Micro Cylindrical Pillars for Cell Sorting

Yusuke Takahashi, Shigehiro Hashimoto, Haruka Hino, Tatsuki Azuma


Micro slits have been designed between micro cylindrical pillars to sort biological cells. Micro cylindrical pillars of 0.02 mm diameter and 0.055 mm height were fabricated on the glass plate using the photolithography technique. Variation was made on the gap between pillars: 0.01 mm, 0.02 mm, 0.03 mm, and 0.04 mm. The micro pillars are set in the flow path between parallel plates, of which dimension of the cross section is 5 mm width and 0.055 mm height. Three kinds of biological cells were used in the test alternatively: C2C12 (mouse myoblast cell line originated with cross-striated muscle of C3H mouse), Hepa1-6 (mouse hepatoma cell line of C57L mouse), or swine red blood cell. The suspension of cells was introduced into the slits by the syringe pump at the flow rate between 0.4 and 500 cm3/hour. The deformation of the cell at the slit can be observed by the microscope. The experimental results show that the designed slit has capability for sorting cells according to the size and deformability of the cell.

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