Journal of
Systemics, Cybernetics and Informatics

ISSN: 1690-4524 (Online)

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Editorial Advisory Board's Chair
William Lesso

Nagib C. Callaos

Sponsored by
The International Institute of
Informatics and Systemics

Editorial Advisory Board


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Integrating Reviewing Processes

Overall Development Management Model: A New Approach for Emerging Countries. Comparative Analysis of Six Countries on Two Continents.
Fabiana Sciarelli, Azzurra Rinaldi
(pages: 1-7)

The Review Function in Organizations and its Implications for Organization Theory, Cybernetics, and Ethnography
Paul D. Nugent, Richard Montague
(pages: 8-12)

Measuring the Value of Enterprise Architecture on IT Projects with CHAOS Research
Eaglan Kurek, James Johnson, Hans Mulder
(pages: 13-18)

Student-Lead, Interdisciplinary Project-Based Learning for Continuous Success in Animation Education
Seth Holladay, Brent Adams
(pages: 19-24)

Increasing the Attractiveness of Study Programs in the Field of Security and Safety
Eva Sventekova, Katarina Holla
(pages: 25-28)

METEO11 Meteorological Message gained from the METB3, METCM or Abstract of Measured Meteorological Data
Karel Šilinger, Martin Blaha
(pages: 29-34)

Transdisciplinar Meta-Design for Geomatics Applications
Margarita Paras Fernandez, Fernando Lopez Caloca
(pages: 35-40)

Biomonapp’s Sensing & Monitoring of Plants/Fish & Water Quality for Ag Biotech & Bio Monitoring Environments
Christine M. Cunningham Yukech
(pages: 41-47)

Data Binding Issue in Fire Control Application for Technical Control of Artillery Fire
Martin Blaha, Karel Šilinger, Ladislav Potužák
(pages: 48-52)

Explaining the AMST Model: Using Arts, Maths, Science, and Technology in an Upgraded Problem-Based Learning Approach
Georgia Daleure
(pages: 53-56)

Challenges for Using IT in Mexico’s Health Care Industry (Aguascalientes México Case)
Jesús Salvador Vivanco, Martha González
(pages: 57-61)

Dialectal Atlas of the Arab World - between Intention and Reality
Anass Bayaga, Olga Bernikova
(pages: 62-65)

Integrating Architectural Approaches in Communication Design Education to Improve Awareness in Affordance Design
Simge Esin Orhun
(pages: 66-71)

Ethical Implications in the Way Some Marketing Activities is Using Big Data
Adriana da Glória Prado, Joice Chiareto, Fábio Lotti Oliva, Celso Cláudio de Hildebrand e Grisi
(pages: 72-76)

Evidence-Based Education: Case Study of Educational Data Acquisition and Reuse
Katashi Nagao, Naoya Morita, Shigeki Ohira
(pages: 77-84)





Optimal Combination of Glycan-Based Serum Diagnostic Markers Which Maximize AUC

Marko I. Vuskovic, Haofei Fang, Harvey I. Pass, Margaret E. Huflejt

Recently a new high-throughput biomarker discovery platform based on printed glycan arrays (PGA) has emerged. PGAs are similar to DNA arrays but contain deposits of various carbohy-drate structures (glycans) instead of spotted DNAs. PGA-based biomarker discovery for the early detection, diagnosis and prognosis of human malignancies is based on the response of the immune system as measured by the level of binding of anti-glycan antibodies from human serum to the glycans on the ar-ray. Since the PGA offer a multitude of markers which can have moderate individual diagnostic power they can be combined in order to achieve maximal classification precision assessed by the popular performance measure area under the ROC curve (AUC). This paper presents an empirical analysis of several combination approaches including those that are specifically designed to maximize the AUC and those that are not, such as Fisher Linear Discriminant, Support Vector Machines and Gen-eralized Linear Model. The analysis is performed on real-life PGA data from three pilot studies involving malignant mesothe-lioma, lung cancer and ovarian cancer.

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