Simulation of Cell Group Formation Regulated by Coordination Number,
Cell Cycle and Duplication Frequency
Shigehiro Hashimoto, Motofumi Toda, Masa Mizobuchi, Takashi Kuromitsu
The effects of coordination number, a cell cycle and duplication
frequency on cell-group formation have been investigated in a
computer simulation. In the simulation, multiplication occurs
in the last three steps of a cell cycle with a probability function
to give variations in the interval. Each cell has a constant
coordination number: four or six. When a cell gets surrounded
by adjacent cells, its status changes from an active stage to a
resting stage. Each cell repeats multiplication, and disappears
when the times of multiplication reach to the limit. Variation
was made in the coordination number, in the interval of
multiplication and in the limited times of multiplication. The
cells of the colony, which have the larger number of
coordination, have reached the larger maximum population and
disappeared earlier. Full Text
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