Supporting a Knowledge Base With Evidence Retrieved From Randomized Controlled Clinical Trials: A Case Study
Marly G. F. Costa, Gisele R. Vieira, Cicero F. F. Costa Filho
This work describes a methodology based on Evidence-Based
Medicine for finding literature–based evidence for a clinical
decision support system. As an illustration, we applied this
method to parenteral nutrition therapy (PNT). PNT requires
expertise and experience and is prone to errors. The Pico’s
strategy was used to built structured clinical questions, which
considered 11 PN clinical indications plus a PN nutrient (amino
acid, glucose, lipid, electrolyte, trace elements and vitamins),
and an outcome. 211 PICO strategies were structured, and 447
searches at PubMed were performed. The results were
classified in levels of evidence and recommendation grades
according to criteria of the Oxford Centre for Evidence Based
Medicine. Full Text
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