This study aims to show results of employing a case study in the use of Active Learning Practices in the Computer Architecture discipline. The practice in question is the use of Marie® CPU Simulator as a practical tool in the development of the course. The methodology of the study aims to verify whether the use of Marie® CPU Simulator contributes to improving the learning of the Computer Architecture discipline, especially whether it provides a better understanding of the parts that integrate the architecture of a given CPU, with an explanation of the function of the parts, and their interrelationship. This study shows the first results of a more comprehensive study on the use of active learning practices, using software in high-tech disciplines of an information system course. The secondary purpose is to show the application of the case study as a methodology outside the usual areas, such as: medicine, psychology and business administration. This study seeks to show the advantages and limitations found, highlighting its potential in the academic field in relation to the use of active learning practices in lessons of technical subjects, such as Computer Architecture, without losing scientific thoroughness in data processing and in the research methodology.