Journal of
Systemics, Cybernetics and Informatics

ISSN: 1690-4524 (Online)

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Honorary Editorial Advisory Board's Chair
William Lesso (1931-2015)

Nagib C. Callaos

Sponsored by
The International Institute of
Informatics and Systemics

Editorial Advisory Board


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Industry and Academic Partnership Leads to Student Driven Success Using an Innovative Cloud Product in the Classroom
Jill Anne O’Sullivan, Sayem Shahrier
(pages: 1-3)

The Use of Virtual Reality in Enhancing Interdisciplinary Research and Education
Tiffany Leung, Farhana Zulkernine, Haruna Isah
(pages: 4-9)

Creation of Support Ecosystem for Innovative Fast Growing Companies
Maja Tomanic Vidovic
(pages: 10-15)

Could e-Government Development Reduce Corruption in South America?
Romel Tintin, Patricio Altamirano, Carmen Chávez, Liliana Tintin
(pages: 16-21)

Blockchain: Next Generation Supply Chain Security for Energy Infrastructure and NERC Critical Infrastructure Protection (CIP) Compliance
Michael Mylrea, Sri Nikhil Gupta Gourisetti
(pages: 22-30)

Flexible Organic Battery Technology Applied in OLED
Andre F. S. Guedes, Simone Tartari, Vilmar P. Guedes, Idaulo J. Cunha
(pages: 31-34)

Information Gathering System Based on BLE Communication for Bus Information Sharing
Katsuhiro Naito, Katsuyuki Tanaka
(pages: 35-41)

Preparing Teachers for Medical Education Using ICT: Achievements and Challenges of an Educational Intervention in a National University in Perú
Maritza Placencia Medina, Rosa Pando Álvarez, Victor Mechan Mendez, Margot Rosario Quintana Salinas, Javier Silva Valencia, Jorge Raúl Carreńo Escobedo, Hubert James Mendoza Rojas, Yanelli Karen Ascacivar Placencia
(pages: 42-47)

Blockchain and Data Protection: The Value of Personal Data
Nicola Fabiano
(pages: 48-51)

Comparative Analysis between Routing Methods Systems Applied to the Rural School Transport Problem in Brazil
Marcelo Franco Porto, Nilson Tadeu Ramos Nunes, Izabela Ribas Vianna de Carvalho, Raphael Bruno Alves Teixeira, Marina Oliveira Fonseca, Lucas Vinicius Ribeiro Alves, Renata Maria Abrantes Baracho
(pages: 52-57)

Humboldt’s Vision of a Smart(er) World
Detlev Doherr, Andreas Jankowski
(pages: 58-60)





Functional Magnetic Resonance Imaging of Goal-Directed Reaching in Children with Autism Spectrum Disorders: A Feasibility Study

Nicole M. G. Salowitz, Bridget Dolan, Rheanna Remmel, Amy Vaughan Van Hecke, Kristine Mosier, Lucia Simo, Robert A. Scheidt

An unanswered question concerning the neural basis of autism spectrum disorders (ASD) is how sensorimotor deficits in individuals with ASD are related to abnormalities of brain function. We previously described a robotic joystick and video game system that allows us to record functional magnetic resonance images (FMRI) while adult humans make goal-directed wrist motions. We anticipated several challenges in extending this approach to studying goal-directed behaviors in children with ASD and in typically developing (TYP) children. In particular we were concerned that children with autism may express increased levels of anxiety as compared to typically developing children due to the loud sounds and small enclosed space of the MRI scanner. We also were concerned that both groups of children might become restless during testing, leading to an unacceptable amount of head movement. Here we performed a pilot study evaluating the extent to which autistic and typically developing children exhibit anxiety during our experimental protocol as well as their ability to comply with task instructions. Our experimental controls were successful in minimizing group differences in drop-out due to anxiety. Kinematic performance and head motion also were similar across groups. Both groups of children engaged cortical regions (frontal, parietal, temporal, occipital) while making goal-directed movements. In addition, the ASD group exhibited task-related correlations in subcortical regions (cerebellum, thalamus), whereas correlations in the TYP group did not reach statistical significance in subcortical regions. Four distinct regions in frontal cortex showed a significant group difference such that TYP children exhibited positive correlations between the hemodynamic response and movement, whereas children with ASD exhibited negative correlations. These findings demonstrate feasibility of simultaneous application of robotic manipulation and functional imaging to study goal-directed motor behaviors in autistic and typically developing children. The findings also suggest the presence of marked changes in neural activation during a sensorimotor task requiring goal-directed movement.

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